Cap Analogs

5’ cap structure of messenger RNA (mRNA) prevents degradation of the mRNA in the cytoplasm and promotes ribosome recruitment and protein translation. Cap analogs can be used to initiate transcription, which eliminates the need for an additional enzymatic capping step.

CleanCap® technology is a “one-pot” solution that reduces the number of steps, equipment required, and time to produce a 5’ Cap 1 mRNA structure with 95% efficiency, providing a modern alternative to enzymatic capping.

Our CleanCap reagents are available in “Research Use” grade as well as GMP-grade “For Further Processing.” GMP product is manufactured in accordance with ISO 9001:2015 and Quality Standards as defined in a GMP Quality Agreement, and must be further processed by the client.

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