N1-Methyl-Pseudouridine-5'-Triphosphate - (N-1081)

N1-Methylpseudouridine-5'-Triphosphate, N1meΨTP, m1ΨTP
SKU Unit Size Price Qty
N-1081-1 1 µmole
$99.00
N-1081-5 5 µmole
$465.00
N-1081-10 10 µmole
$819.00
N-1081-100 100 µmole
$5,200.00

Description

N1-Methyl-Pseudouridine-5'-Triphosphate, sodium salt, is a modified NTP for incorporation into messenger RNAs (mRNA) using T7 RNA Polymerase. Incorporation of N1-Methyl-Pseudouridine can reduce the immunogenicity of the resulting mRNA.

Product Details

Catalog No N-1081
Purity ≥99% by AX-HPLC
Extinction Coefficient 8,877 Lmol-1cm-1 at 271 nm
Molecular Formula C10H17N2O15P3 (free acid)
Molecular Weight 498.10 g/mole (free acid)
Salt Form Na+
Concentration 100 mM
Buffer H2O
Recommended Storage -20°C or below
Other Name(s) N1-Methylpseudouridine-5'-Triphosphate, N1meΨTP, m1ΨTP
Application In vitro Transcription
Backbone 5'-Triphosphate
Base Analog(s) Pseudouridine
Sugar Type(s) RNA
Nucleotide Category Base Modified RNA

Supporting Documents



Certificate of Analysis


Intellectual Property

Products are for research use only, not for use in diagnostic or therapeutic procedures or for use in humans. Products are not for resale without express written permission of Seller. No license under any patent or other intellectual property right of Seller or its licensors is granted or implied by the purchase unless otherwise provided in writing.

TriLink does not warrant that the use or sale of the products delivered hereunder will not infringe the claims of any United States or other patents or patents pending covering the use of the product alone or in combination with other products or in the operation of any process. All and any use of TriLink product is the purchaser's sole responsibility.



References

Pardi, Norbert; Tuyishime, Steven; Muramatsu, Hiromi; Kariko, Katalin; Mui, Barbara L.; Tam, Ying K.; Madden, Thomas D.; Hope, Michael J.; Weissman, Drew . Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes.

Pardi, Norbert; Parkhouse, Kaela; Kirkpatrick, Ericka; McMahon, Meagan; Zost, Seth J.; Mui, Barbara L.; Tam, Ying K.; Karikó, Katalin; Barbosa, Christopher J.; Madden, Thomas D.; Hope, Michael J.; Krammer, Florian; Hensley, Scott E.; Weissman, Drew . Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies.

Tiwari, Pooja Munnilal; Vanover, Daryll; Lindsay, Kevin E.; Bawage, Swapnil Subhash; Kirschman, Jonathan L.; Bhosle, Sushma; Lifland, Aaron W.; Zurla, Chiara; Santangelo, Philip J. . Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection.

Laczk . A single immunization with nucleoside-modified mRNA vaccines elicits strong cellular and humoral immune responses against SARS-CoV-2 in mice

Lockhart, JH;VanWye, J;Banerjee, R;Wickline, SA;Pan, H;Totary-Jain, H; . Self-assembled miRNA-switch nanoparticles target denuded regions and prevent restenosis

Leppek, K;Byeon, GW;Kladwang, W;Wayment-Steele, HK;Kerr, CH;Xu, AF;Kim, DS;Topkar, VV;Choe, C;Rothschild, D;Tiu, GC;Wellington-Oguri, R;Fujii, K;Sharma, E;Watkins, AM;Nicol, JJ;Romano, J;Tunguz, B;Participants, E;Barna, M;Das, R; . Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics

Chen, PJ;Hussmann, JA;Yan, J;Knipping, F;Ravisankar, P;Chen, PF;Chen, C;Nelson, JW;Newby, GA;Sahin, M;Osborn, MJ;Weissman, JS;Adamson, B;Liu, DR; . Enhanced prime editing systems by manipulating cellular determinants of editing outcomes

Everton, E;Rizvi, F;Smith, AR;Beattie, M;Tam, Y;Pardi, N;Weissman, D;Gouon-Evans, V; . Transient yet Robust Expression of Proteins in the Mouse Liver via Intravenous Injection of Lipid Nanoparticle-encapsulated Nucleoside-modified mRNA

Appelberg, S;John, L;Pardi, N;V . Nucleoside-modified mRNA vaccines protect IFNAR-/- mice against Crimean Congo hemorrhagic fever virus infection

Matias, J;Kurokawa, C;Sajid, A;Narasimhan, S;Arora, G;Diktas, H;Lynn, GE;DePonte, K;Pardi, N;Valenzuela, JG;Weissman, D;Fikrig, E; . Tick immunity using mRNA, DNA and protein-based Salp14 delivery strategies

Svitkin, YV;Gingras, AC;Sonenberg, N; . Membrane-dependent relief of translation elongation

Parhiz, H;Brenner, JS;Patel, P;Papp, TE;Shahnawaz, H;Li, Q;Shi, R;Zamora, M;Yadegari, A;Marcos-Contreras, OA;Natesan, A;Pardi, N;Shuvaev, VV;Kiseleva, R;Myerson, J;Uhler, T;Riley, RS;Han, X;Mitchell, MJ;Lam, K;Heyes, J;Weissman, D;Muzykantov, V; . Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE)

Whitley, J;Zwolinski, C;Denis, C;Maughan, M;Hayles, L;Clarke, D;Snare, M;Liao, H;Chiou, S;Marmura, T;Zoeller, H;Hudson, B;Peart, J;Johnson, M;Karlsson, A;Wang, Y;Nagle, C;Harris, C;Tonkin, D;Fraser, S;Capiz, L;Zeno, CL;Meli, Y;Martik, D;Ozaki, DA;Caparoni, A;Dickens, JE;Weissman, D;Saunders, KO;Haynes, BF;Sempowski, GD;Denny, TN;Johnson, MR; . Development of mRNA manufacturing for vaccines and therapeutics: mRNA platform requirements and development of a scalable production process to support early phase clinical trials

Aditham, A;Shi, H;Guo, J;Zeng, H;Zhou, Y;Wade, SD;Huang, J;Liu, J;Wang, X; . Chemically Modified mocRNAs for Highly Efficient Protein Expression in Mammalian Cells

Ge, N;Sun, J;Liu, Z;Shu, J;Yan, H;Kou, Z;Wei, Y;Jin, X; . An mRNA vaccine encoding Chikungunya virus E2-E1 protein elicits robust neutralizing antibody responses and CTL immune responses

Liu, W;Alameh, MG;Yang, JF;Xu, JR;Lin, PJC;Tam, YK; . Lipid nanoparticles delivering constitutively active STING mRNA as a novel anti-cancer therapeutic approach



""