Optimize Production of mRNA Therapeutics,
from Clinical to Commercial

CleanCap® Reagents: A Novel mRNA Capping Solution

CleanCap technology is a “one-pot” solution that reduces the number of steps, equipment required, and time to produce a 5’ Cap 1 mRNA structure with 95% efficiency, providing a modern alternative to enzymatic capping. Available in GMP grade, CleanCap reagents offer an immediate solution for swiftly scaling from clinical to commercial.

The CleanCap Technology Advantage

As a revolutionary solution to mRNA capping for vaccine and therapeutic production, CleanCap technology offers many advantages over traditional enzymatic capping:

  • Natural Cap 1 Structure
  • 3x Transcriptional Yield
  • One-Pot Synthesis for Superior Efficiency
  • Reduces Immunogenicity
  • GMP Grade Available

Tried and Trusted Technology

Used in global commercial manufacturing programs, including a leading COVID-19 vaccine, CleanCap technology has proven to be the optimal mRNA vaccine capping method. See how we ramped up production to meet unprecedented demands in the global pandemic. View case study >

A New Level of Performance and Efficiency

See how the evolution of cap analogs led to the creation of CleanCap technology and the enablement of a single,
co-transcriptional in vitro transcription reaction for manufacturing mRNA.

Accelerate Your mRNA Therapeutic Development

CleanCap technology is the fastest and easiest way to produce a 5’ Cap 1 mRNA structure with 95% efficiency. The “one-pot” solution requires fewer steps and less equipment than enzymatic capping—allowing for:

  • Quicker Process

  • Greater Production Potential

  • Better Return


Applications for CleanCap Reagents

CleanCap reagents are advancing some of the most cutting-edge pharmaceuticals and biotechnologies on the market today. Recognized as the superior capping method, CleanCap analogs are the future of mRNA therapeutic production.


Cell Therapy


Gene Editing

Find the CleanCap Reagent That’s Right for You

From research use to GMP grade, CleanCap technology is available in a variety of formats to meet your unique production needs:

  • GMP Custom mRNA Manufacturing
  • Custom mRNA Manufacturing
  • Capping Reagent—Research and GMP Grades
  • Stocked mRNA with CleanCap Reagent AG

Discover How to Enhance Your mRNA Production Today 

Ready to elevate your mRNA therapeutic development process?
Talk to our team about what may be the best option for you. Fill out the form below to get started.

CleanCap Brochure Download

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