7-Deazaguanosine-5'-Triphosphate - (N-1044)

7-Deaza-GTP

This product is now available upon request as a custom synthesis. It is not maintained as a stocked item.

Description

7-Deazaguanosine-5'-Triphosphate is a guanosine triphosphate analog which lacks a nitrogen at the N7 position of the nucleobase. Replacement of this nitrogen atom with a carbon atom results in diminished structure of the major groove in DNA and may disrupt base stacking, but does not interfere with Watson-Crick base pairing. This is desirable for applications such as amplification and sequencing of GC-rich nucleic acid sequences.

Product Details

Catalog No N-1044
Purity ≥90% by AX-HPLC
Extinction Coefficient 9,145 Lmol-1cm-1 at 259 nm
Molecular Formula C11H17N4O14P3 (free acid)
Molecular Weight 522.10 g/mole (free acid)
Salt Form Li+
Concentration 100 mM
Buffer H2O
Recommended Storage -20°C or below
Other Name(s) 7-Deaza-GTP
Application Aptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies
Backbone 5'-Triphosphate
Base Analog(s) Guanosine
Sugar Type(s) RNA
Nucleotide Category Base Modified RNA

Supporting Documents



Certificate of Analysis


Intellectual Property

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References

Chugani, S. A.; Parsek, M. R.; Chakrabarty, A. M. . Transcriptional repression mediated by LysR-type regulator CatR bound at multiple binding sites.

Amara, Amro A.; Rehm, Bernd H. A. . Replacement of the catalytic nucleophile cysteine-296 by serine in class II polyhydroxyalkanoate synthase from Pseudomonas aeruginosa-mediated synthesis of a new polyester: identification of catalytic residues.

Paranagama, Naduni; Bonnett, Shilah A.; Alvarez, Jonathan; Luthra, Amit; Stec, Boguslaw; Gustafson, Andrew; Iwata-Reuyl, Dirk; Swairjo, Manal A. . Mechanism and catalytic strategy of the prokaryotic-specific GTP cyclohydrolase-IB.

Waldron, Joseph A.; Raza, Farheen; Le Quesne, John . eIF4A alleviates the translational repression mediated by classical secondary structures more than by G-quadruplexes.

Nakamura, Akiyoshi; Wang, Daole; Komatsu, Yasuo . Molecular mechanism of substrate recognition and specificity of tRNA(His) guanylyltransferase during nucleotide addition in the 3'-5' direction.

Herviou, P;Le Bras, M;Dumas, L;Hieblot, C;Gilhodes, J;Cioci, G;Hugnot, JP;Ameadan, A;Guillonneau, F;Dassi, E;Cammas, A;Millevoi, S; . hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma

Waldron, JA;Raza, F;Le Quesne, J; . eIF4A alleviates the translational repression mediated by classical secondary structures more than by G-quadruplexes

Ebenhoch, R;Prinz, S;Kaltwasser, S;Mills, DJ;Meinecke, R;R . A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I

Ebenhoch, R;Bauer, M;Reinert, D;Kersting, A;Huber, S;Schmid, A;Hinz, I;Feiler, M;M . Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP



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