2-Amino-2'-deoxyadenosine-5'-Triphosphate - (N-2003)

2,6-Diaminopurine-2'-deoxyribose-5'-Triphosphate, 2-Amino-dATP, DAP-drTP
SKU Unit Size Price Qty
N-2003-1 1 µmole
$99.00
N-2003-5 5 µmole
$497.00
N-2003-10 10 µmole
$876.00

Description

Substitution of 2-Amino-2'-deoxyadenosine (also known as 2,6-Diaminopurine-2'-deoxyribose) for adenine in DNA can result in increased stabilization of the DNA duplex. Diaminopurine base pairs with thymine forming three intramolecular hydrogen bonds versus two for adenine.

Product Details

Catalog No N-2003
Purity ≥90% by AX-HPLC
Extinction Coefficient 8,743 Lmol-1cm-1 at 279 nm
Molecular Formula C10H17N6O12P3 (free acid)
Molecular Weight 506.20 g/mole (free acid)
Salt Form Li+
Concentration 100 mM
Buffer H2O
Recommended Storage -20°C or below
Other Name(s) 2,6-Diaminopurine-2'-deoxyribose-5'-Triphosphate, 2-Amino-dATP, DAP-drTP
Application Aptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies
Backbone 5'-Triphosphate
Base Analog(s) Adenosine
Sugar Type(s) DNA
Nucleotide Category Base Modified DNA

Supporting Documents



Certificate of Analysis


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References

Wood, David O.; Dinsmore, Michael J.; Bare, Grant A.; Lee, Jeremy S. . M-DNA is stabilised in G*C tracts or by incorporation of 5-fluorouracil.

Kutyavin, Igor V. . Use of Base-Modified Duplex-Stabilizing Deoxynucleoside 5′-Triphosphates To Enhance the Hybridization Properties of Primers and Probes in Detection Polymerase Chain Reaction†

Kawai, Kiyohiko; Kodera, Haruka; Majima, Tetsuro . Photocatalytic formation of I-I bonds using DNA which enables detection of single nucleotide polymorphisms.

Devadoss, Babho; Lee, Irene; Berdis, Anthony J. . Enhancing the "A-rule" of translesion DNA synthesis: promutagenic DNA synthesis using modified nucleoside triphosphates.

Zhang, Xuemei; Motea, Edward; Lee, Irene; Berdis, Anthony J. . Replication of a Universal Nucleobase Provides Unique Insight into the Role of Entropy during DNA Polymerization and Pyrophosphorolysis

Patro, Jennifer N.; Urban, Milan; Kuchta, Robert D. . Role of the 2-amino group of purines during dNTP polymerization by human DNA polymerase alpha.

Trostler, Michael; Delier, Alison; Beckman, Jeff; Urban, Milan; Patro, Jennifer N.; Spratt, Thomas E.; Beese, Lorena S.; Kuchta, Robert D. . Discrimination between right and wrong purine dNTPs by DNA polymerase I from Bacillus stearothermophilus.

Fernández-Sierra, Mónica; Shao, Qing; Fountain, Chandler; Finzi, Laura; Dunlap, David . E. coli Gyrase Fails to Negatively Supercoil Diaminopurine-Substituted DNA.

Strobel, E; . Preparation and Characterization of Internally Modified DNA Templates for Chemical Transcription Roadblocking



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